Deinoksantinin HER2 Pozitif Meme Kanserinde Tamoksifenin Antiproliferatif Aktivitesi Üzerindeki Agonistik Etkileri: MDA-MB-453 Üzerine Bir In vitro Çalışma

A good understanding of the pathogenesis breast cancer, in which 2020 an estimated 684,996 women across world died, plays a vital role development treatment methods. In recent years, estrogen receptor (ER), progesterone (PR), and Epidermal Growth Factor receptor-2 (HER2) expression levels have been substantial prognostic markers. The combinational therapy approach is use two or more active ingredients most important benefit this method to reduce drug resistance since probability carcinoma being resistant than one at same time low. Tamoxifen, competitive nonsteroidal drug, has used for nearly 20 years treat patients with hormone receptor-positive cancer. Deinoxanthin xanthophyll derivative purified from cell wall radiation-resistant bacterium, Deinococcus radiodurans. This xanthine shown some studies proapoptotic antiproliferative effects on types Within study's scope, it aimed increase effectiveness Tamoxifen deinoxanthin. Using ACTB gene as reference investigate synergistic effect deinoxanthin MDA-MB-453 cancer line; Expression BAX, CASP-3, BCL-2, HER2 genes were examined by RT-qPCR method. ELISA determined amounts proteins compared them results. It was that positive line increased combination